Houston's offense struggled to get going, managing only six hits in the game and four off Cubs starter Travis Wood. Wood (6-11) pitched 7 2/3 innings, giving up one run and striking out six.
The Astros' lone run came in the eighth when Fernando Martinez pinch-hit an RBI single to score Brandon Barnes immediately after Wood was replaced by Shawn Camp. Fernandez is 9-for-19 in September, via MLB.com's Brian McTaggert.
Chicago opened the scoring with an RBI single from Welington Castillo in the first inning. Alfonso Soriano pushed the lead to 2-0 with a solo homer in the fifth and to 3-0 with an RBI single in the seventh.
Houston used six pitchers in the game, including Mickey Storey, who took a liner in the face from Dave Sappelt in the eighth and had to leave the game. Fernando Abad (0-4) started and took the loss after giving up one run and four hits in 3 1/3 innings.
The Astros scored one run in each of the three games in the series, dropping two of three. They will open a four-game home series against the Philadelphia Phillies on Thursday night at 7:05 p.m. CT.
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