With a win against the Patriots, the Texans can clinch the AFC South, but the team would also need the Colts to lose on Sunday.
Both the Texans and the Patriots earned playoff spots in Week 13, although Houston still hasn't quite locked up the AFC South. With a three-game lead and four games to play, including a pair of games between the Texans and Colts, a win against the Patriots wouldn't be enough to clinch the division by itself.
However, a win on Monday night, coupled with a Colts loss would do the trick. The Colts host the Tennessee Titans on Sunday, six weeks after defeating the Titans, 19-13, in Week 8.
The Texans may also want to keep an eye on the Broncos and Ravens, as both teams are two games behind the Texans for the AFC's top seed in the playoffs. The Broncos will travel to Oakland for a Thursday Night Football game while the Ravens will try to bounce back from a loss in a road trip to play the Washington Redskins.