Houston is in the middle of a stretch of six home games in two weeks, and a win over San Antonio would be the biggest hurdle for the Rockets to go undefeated in that span and insert themselves directly into the Western Conference playoff race.
The Spurs have been able to weather the loss of Manu Ginobili, going 7-3 in their star guard's absence. Tony Parker has assumed much of the scoring load, as the three-time All-Star is averaging 16.7 points per game this season.
Saturday's game will be the third match-up between the two Southwest Division rivals this year, with both teams holding serve at home so far.
The schedule will once again work in Houston's favor, as the Spurs have to play the Sacramento Kings at home on Friday before traveling to Houston early Saturday morning.
The 7:00 PM game will be televised regionally on FSN Houston.